There are three Zones in TBM that have a detrimental effects, Plane of Health, Crypt of Decay, and Crypt of Sul. Are these effects able to be removed or reduced by quests or progression?
Must have missed the issue in Plane of Health. As for the hp/mana cap in the crypts the answer is yes. Completing all of the tasks removes that effect. You would think that lesser spirit armor would be all you need from the description but its not. It only lessens the effect a tiny bit. You need to complete ALL the tasks in both zones to completely block the effect. IE merc and partisan. I don't remember if you have to do all the missions as well or not.
Lesser Spirit Armor: Plane of Health Partisan 6x DemiLife Partisan 6x DemiDecay Partisan 6x Crypt of Decay Partisan 6x Crypt of Sul Mercenary Crypt of Sul Partisan Crypt of Sul Hero Missions You shouldn't need the achievements to get rid of the debuffs, but you'll want to do them anyway for the Relife Adornment. The debuffs are silly because they basically only matter to the tank (less healing received in Health and HP capped in the Crypts), and don't exist at all in the instances.
You do not need challenger but everything else, Mercenary, Partisan, Hero, Lesser Spirit Armor.and the side quests:Breaking the Mirror to get it completely blocked.