To spend 70 years of your life with someone and then they are not there one morning must be incredibly devastating. Even though Stan is credited as being the "grandfather" of the Marvel universe, anyone who enjoys any comics owes him a debt of gratitude.
She voiced Madame Web in the 1994 Spider-Man cartoon series, and she and Stan had a nice little moment of sorts in the final episode. It's around the 1:27 mark. Rest in peace, dear lady.