I'm struggling with the first encounter, Gatekeeper Karatil. Whatever I do I can't get his detriments off before he replaces them, and the eventually get one shotted. I've completed all 3 factions quests, got further upgrades from key quests, and upgrades from the tradeskill weeklies. Swashbuckler using Zhugrus Blightstrike. I've not had much difficulty in doing the first 4 signature quests, and I did those before getting the key quest & weekly upgrades. I'm guessing I'm missing something strategy wise here.
I went ahead and just looked the fight over. The reuse of some of his abilities was set to pretty fast. I added some more time between them. Let me know how it goes after next update.